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Viral Hepatitis Reviews
Abstract
Management of the asymptomatic HCV Carrier with Normal ALT
Levels
Patrick Marcellin, Stéphane Levy, Jean-Pierre Benhamou,
Serge Erlinger
A significant proportion of anti-HCV-positive subjects have
normal serum alanine aminotransferase (ALT) levels. Clinical
characteristics of these subjects are not different from those of
anti-HCV-positive patients with mildly increased ALT levels. About
60% of them have detectable serum HCV RNA by polymerase chain
reaction (PCR). Histological studies showed a normal liver, or
non-specific changes, in 27%, chronic persistent hepatitis in 54%,
and chronic active hepatitis in 19%. The long-term outcome of these
patients is unknown but most of them have a very mild disease with
a probable good prognosis. A liver biopsy is unnecessary and there
is no evidence so far that alpha interferon therapy is
beneficial.
p 277-283 Volume 2 Number 4, December 1996
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