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Psychotic Symptoms During Interferon Therapy May Result from
Decreased Cerebral Blood Flow
Regional cerebral blood flow (rCBF) was measured with single
photon emission computed tomography (SPECT) using
N-isopropyl-p-[I-123] iodoamphetamine (I-123-IMP) in a patient with
acute hepatitis C who showed depressive state during interferon
therapy. During his depressive state the rCBF was decreased
markedly in the inferior frontal cortex. This case suggests that
psychotic symptoms during IFN therapy may result from decreased
rCBF.
Author: SASAKI M, KURUME UNIV, SCH MED, DEPT INTERNAL MED 2,
ASAHI MACHI 67, KURUME FUKUOKA 8330 Source: INTERNATIONAL
HEPATOLOGY COMMUNICATIONS 1996 OCT;5(6):354-360
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