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FULL OR PARTIAL SEROREVERSION IN PATIENTS INFECTED BY HEPATITIS
C VIRUS
Cases of partial seroreversion have been reported in
hemodialyzed or immunodepressed patients, but spontaneous clearance
of viremia associated with a disappearance of specific antibodies
or clearance while receiving therapy has not been precisely
documented in immunocompetent hepatitis C virus (HCV)-infected
persons. A longitudinal study of markers of HCV infection in a
cohort of 178 multitransfused patients followed over an 8-year
period was done to establish well-documented cases of partial or
full seroreversion. Thirty (16.8%) of 178 patients were
HCV-infected; among them, 5 had partial or full seroreversion.
Seroreversion to an anti-HCV-negative state is characterized by a
quantitative decrease in antibody, A seroreversion may be observed
in three circumstances: spontaneously, induced by therapy, and in
conjunction with human immunodeficiency virus infection. Long-term
follow-up of seroreverters will establish whether they have
definitively eradicated HCV from their systems.
Author: LEFRERE JJ, HOP ST ANTOINE, INST NATL TRANSFUS
SANGUINE, 53 BLVD DIDEROT, F-75012 PARIS, FRANCE
Source: JOURNAL OF INFECTIOUS DISEASES 1997
FEB;175(2):316-322
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