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Cutaneous necrosis associated with interferon alpha-2b
Cutaneous necrosis may occur as a complication of treatment with
interferon. Here we report the first case of cutaneous necrosis
developing in a patient receiving interferon alpha-2b for the
treatment of chronic hepatitis C viral infection. The patient
developed two necrotic lesions while receiving high doses of
interferon. We suggest that discontinuation of treatment may be
necessary to permit healing of such lesions. Although the exact
mechanism involved in cutaneous necrosis remains unknown, our
observations support earlier findings suggesting that intraarterial
injection may be a factor.
AUTHOR: Sickler JB, Simmons RA, Cobb DK, Sherman KE,
University of Cincinnati Medical Center, Ohio 45267, USA.
SOURCE: Am J Gastroenterol 1998 Mar;93(3):463-464
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