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WESTPORT, Feb 19, 1996 (Reuters)
While interferon-alpha 2B is known to be effective in some
patients with chronic hepatitis C viral infection, few patients
have a sustained response when the drug is given in standard doses.
That prompted Dr. Herbert L. Bonkovsky and colleagues at the
University of Massachusetts at Worcester to test whether higher
doses of the drug would be effective.
Twenty-four patients who had failed to respond to standard
interferon therapy or had relapsed after an initially successful
course of interferon therapy were randomized to receive higher
doses, either 15 million units or 22.5 to 30 million units weekly
for 24 weeks. Only one patient had a sustained response, leading
the researchers to conclude that high-dose therapy is seldom
beneficial and causes more side effects, as well.
Digest Dis Sci 1996;41:149-153.
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