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Characteristics of Complete Responders to Interferon
Patients with chronic hepatitis C with high serum levels of HCV
RNA are less likely to show a complete response to IFN therapy than
those with a low serum levels of HCV RNA. The characteristics of
patients with high serum levels of HCV RNA who show a complete
response to IFN therapy have not been evaluated in detail. We
retrospectively analyzed the 121 patients with high serum levels of
HCV RNA (greater than or equal to 1.0 Meq/ml) before IFN therapy to
determine the characteristics of complete responders. A complete
response to IFN was observed in 12 (9.9%) of 121 patients. There
was no difference between complete responders and non-responders in
age, the result of liver function tests, or liver histology. In all
complete responders, pretreatment serum level of HCV RNA was less
than 5.0 Meq/ml, which was significantly lower than the level in
the non-responders (P < 0.01). The fluctuation of HCV RNA level
less than 0.5 Meq/ml was observed in ten of the 12 complete
responders. The frequency of serotype 2 was significantly higher in
the complete responders compared with the non-responders (P <
0.05). These findings suggest that complete responders are rare
among patients with serum levels of HCV RNA 2 5.0 Meq/ml. In
planning IFN therapy, fluctuations in the HCV RNA level, as well as
the serotype, should be considered. (C) 1997 Elsevier Science
Ireland Ltd.
Author: IDE T, KURUME UNIV, SCH MED, DEPT INTERNAL MED 2, 67
ASAHI MACHI, KURUME FUKUOKA 830 Source: HEPATOLOGY RESEARCH 1997
MAY;7(1):19-27
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