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Gastroenterol Nurs 2001 Jul-Aug;24(4):192-6 Related Articles,
Books, LinkOut
Assessment of side effects in patients with chronic hepatitis C
receiving combination therapy.
Zucker DM, Miller BW., School of Nursing, University of
Massachusetts, Amherst, USA.
The purpose of this descriptive study is to review the adverse
effects of combination therapy, interferon alfa-2b and ribavirin,
in a sample of patients with chronic hepatitis C who were part of a
larger multi-center trial (Bonkovsky, 1999). The sample (n = 13)
was drawn from one hepatology practice in the northeastern United
States. This secondary analysis reported sums, frequencies, means,
and standard deviations for the sample. Patients who received 600
mg ribavirin per day in addition to interferon alfa-2B (Arm A)
showed a mean of 9.5 different types of side effects. Patients who
received 1000-1200 mg of ribavirin in addition to interferon
alfa-2B (Arm B) had a mean of 8.6 different types of side
effects.
The highest-ranking side effects were:
fatigue (92%), = (really really tired feeling that rest & naps
don't help)
insomnia (85%), = (can't sleep)
alopecia (69%), = (hair loss)
arthralgia (62%). = (all types of arthritis)
A secondary analysis of the entire data set is required before
confidence can be placed in the findings. Implications for nursing
practice include the need for creative strategies to reduce the
effects of fatigue, insomnia, alopecia, and arthralgia in patients
with chronic hepatitis C.
Source PMID: 11848003
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