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J Clin Lab Anal 2000;14(3):120-124 Related Articles,
Books
Decrease of HCVRNA after three days of daily interferon treatment
is predictive of the virological response at one month.
Magalini A, Puoti M, Putzolu V, Quiros-Roldan E, Forleo MA, Rossi
S, Zaltron S, Spinetti A, Zanini B, Zonaro A, Solfrini R, Carosi
G
Department of Clinical Chemistry, O.P. Richiedei, Brescia,
Italy.
[Record supplied by publisher]
Early monitoring of HCVRNA during interferon treatment may allow
clinicians to obtain important information that could help them to
adopt therapeutic decisions in individual cases. The hepatitis C
virus infection is highly dynamic and a daily high dose of IFN may
induce a decline of viremia of 95 10% of baseline value after 24 to
48 hours of treatment. The importance of this early antiviral
efficacy has not been understood. We have measured HCVRNA levels in
47 patients with chronic hepatitis C infection during interferon
treatment to study HCVRNA kinetics and evaluate the predictive
value of the early decay of viremia on the virological response
after one month of treatment. Sixty percent of treated patients
showed early virological response (EVR) and it was significantly
associated with low HCVRNA levels and a genotype other than 1b.
Finally, the absence of an 85% decline in HCVRNA levels after 3
days of treatment observed in 11 out of 45 patients (24%) was an
absolute and very early predictor of the absence of EVR in the
study population.
Copyright 2000 Wiley-Liss, Inc., PMID: 10797610
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