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DIMINISHED PLASMA-LEVELS OF VITAMIN-E IN PATIENTS WITH SEVERE VIRAL-HEPATITIS

RRR-alpha-Tocopherol (Vitamin E) was assayed in plasma of 48 patients with viral hepatitis and of 32 healthy controls. In patients with highly elevated serum transaminases (ALT greater than 100 U/L) vitamin E plasma levels were significantly lower (17.5 +/- 4.8 mu mol/L) than in controls (22.7 +/- 4.2 mu mol/L, p less than 0.01). The vitamin E/ lipid ratios (3.12 +/- 0.63 mu mol/g) in these patients were 33% lower than those of the controls (4.68 +/- 0.54 mu mol/g). The lowered vitamin E levels in patients with acute or chronic viral hepatitis with high activity of disease may be due to free radical- mediated liver injury.

Author: H SIES, UNIV DUSSELDORF, INST PHYSIOL CHEM 1, POSTFACH 101007, D-40001 DUSSELDORF, GERMANY
Source: FREE RADICAL RESEARCH 1996 ;25(6):461-466


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