High malignancy of hepatocellular carcinoma in alcoholic
patients with HCV
BACKGROUND:
We investigated the relationships between alcohol consumption, the
degree of malignancy evaluated histologically, and tumor-free
survival rates.
METHODS:
In 80 male patients with the hepatitis C virus and small
hepatocellular carcinomas (diameter of main tumor, 3.0 cm or less),
38 patients had drunk 86 gm or more of ethanol per day for at least
10 years until the detection of hepatocellular carcinoma (group 1),
whereas the remaining 42 patients were nondrinkers or occasional
drinkers (group 2).
RESULTS:
Differences in the results of liver function tests between the
groups were not statistically significant. The operative methods
used in the groups were comparable. The proportion of
well-differentiated hepatocellular carcinoma was lower in group 1
than in group 2 (p < 0.0001). The prevalences of extracapsular
invasion, portal tumor thrombi, and intrahepatic metastasis were
higher in group 1 than in group 2 (p = 0.0085, p = 0.0319, and p =
0.0428, respectively). The tumor-free survival rate after operation
was lower in group 1 than in group 2(p = 0.041 by the log-rank
test; p = 0.032 by the generalized Wilcoxon test).
CONCLUSIONS:
These findings indicate that in group 1, even though tumors were
small, the carcinomas were advanced and the outcomes after surgery
were poor, suggesting that alcohol affects the grade of malignancy
of this disease.
Surgery 121 (4): 425-429 (1997)
Kubo S, Kinoshita H, Hirohashi K, Tanaka H, Tsukamoto T, Shuto T,
Kuroki T
Second Department of Surgery, Osaka City University Medical School,
Japan.
PMID: 9096628, MUID: 97250945
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