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Induction of cytochrome P-448 iso-enzymes and related
glucuronyltransferases in the human liver by cigarette smoking
Fleischmann R; Remmer H; Starz U
Eur J Clin Pharmacol 30: 475-80 (1986)
Abstract
Human liver 10-20 mg from biopsy samples removed for diagnostic
purposes from selected patients has been used for the preparation
of microsomes. The activity of certain mono-oxygenases and
UDP-glucuronyltransferases, as well as certain other enzymes
involved in drug metabolism, has been determined using different
substrates as indicators. Smokers oxidized benzo(a)pyrene and
7-ethoxyresorufin and also conjugated alpha-naphthol at a
significantly increased rate compared to non-smokers. This
indicates induction of certain mono-oxygenases and
glucuronyltransferases which differs from the induction produced by
phenobarbital. The findings can account for the reduced activity
and increased elimination rate of certain drugs prescribed to
smokers.
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