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DISTRIBUTION OF INFECTING HEPATITIS C VIRUS GENOTYPES IN END
STAGE LIVER DISEASE PATIENTS AT A LARGE AMERICAN TRANSPLANTATION
CENTER
The distribution of hepatitis C virus (HCV) genotypes was
studied in 202 anti-HCV-positive liver transplant candidates with
end-stage liver disease. HCV sequences were successfully amplified
from 185 patients: In the first 100, the genotype was determined by
direct sequencing in the NS5 region, and in the remaining 85,
type-specific primers were used for genotyping. Eighty-five
patients (46.0%) were infected with type 1a HCV strains, 52 (28.1%)
with type 1b, 14 (7.6%) with type 2b, 13 (7.0%) with type 4, 5
(2.7%) with type 3a, 2 (1.1%) with type 2a, and 1 (0.5%) with type
2c, Thirteen HCV- positive patients (7.0%) could not be genotyped,
The relatively low prevalence of genotype 1b in this population of
end-stage liver disease patients speaks against postulated higher
pathogenicity of this genotype.
Author: J RAKELA, UNIV PITTSBURGH, PITTSBURGH TRANSPLANTATION
INST, DIV GASTROENTEROLOGY & HEPATOLOGY, 301 LHORMER BLDG,
PITTSBURGH, PA 15213
Source: JOURNAL OF INFECTIOUS DISEASES 1997
FEB;175(2):448-450
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