|
Home
What is
Hepatitis
How is it
Transmitted
Long Term
Prognosis
Complications of
HCV
Liver
Biopsy
Treatment Info
(Interferon, Herbal, etc)
Lab Tests (PCR,
Genotype,etc.)
Nutrition
& Alternative Info
Patient
Information (Support Groups, Doctor Listing,
etc)
Related
Webpages
Transplant
Info
Site
Search
HCV
Webrings
My
guestbookbook
Site
Awards
FAQ &
Disclaimers
|
Lack of correlation between hepatitis C virus genotypes and
clinical course of hepatitis C virus-related cirrhosis.
Benvegnu, L., Pontisso, P., Cavalletto, D., Noventa, F.,
Chemello, L., and Alberti, A. 1997. Hepatology. 25:211-215.
Hepatitis C virus (HCV) is classified into different genotypes
based on sequence differences in the viral genome. Several previous
studies have suggested that some genotypes, generally type 1a and
1b, are associated with more advanced liver disease. For example,
Zein et al. (1996) [see November 1996 Current Papers in Liver
Disease] recently showed that genotypes 1a and 1b, the most
prevalent in the United States, are associated with more severe
liver disease. In this study, the authors studied 429 patients in
Italy with chronic hepatitis C including 109 with cirrhosis. The
patients with cirrhosis were followed prospectively to assess the
role of HCV genotype on disease outcome. Genotype 1 (mainly 1b) was
detected in 46% of patients without cirrhosis and 43% with
cirrhosis (P not significant). Genotype 2 (mainly 2a) was detected
in 32% of individuals without cirrhosis and 27.5% with cirrhosis (P
not significant). Genotype 3 was detected in 10% of patients
without cirrhosis and 2% with cirrhosis (P < 0.005). Mixed
genotype infections were found in 5.5% of individuals, all of whom
had cirrhosis. During a mean follow-up of the patients with
cirrhosis for 67 months, 38.5% had either worsening of Child's
stage, underwent liver transplantation, developed hepatocellular
carcinoma or died. The probability of developing each or at least
one of these events did not differ in relation to the genotype of
infecting HCV, except for a higher incidence of death in
individuals with mixed genotype infections. These results, which
are in contrast to those of several other studies, suggest that HCV
genotype does not have a significant effect on the severity and
progression of liver disease in patients with chronic
hepatitis.
Home | What is HCV | Transmission |
Future |
Complications |
Biopsy |
Treatment
| Lab |
Nutrition |
Patient |
Links | Transplant |
Webrings |
guestbookbook |
Awards |
FAQ
|
|