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Title: Hepatitis C Virus Genotypes In Patients With Persistent
Infection - A Preliminary Report
Hepatitis C virus (HCV) has nucleotide sequence diversity
distributed throughout the viral genome, with variants showing even
less than 70% homology. There is some evidence that sequence
variation of HCV genotypes partly determines the course of
infection and response to treatment with interferon. We studied the
sera of 29 Israeli HCV patients, all suffering from chronic liver
disease, and 34 patients with renal failure necessitating
hemodialysis. HCV genotypes were detected using a reverse
hybridization assay (LiPA), after reverse transcription polymerase
chain reaction, using primers spanning the 5' UTR of the HCV
genome. In this preliminary report the predominant HCV type
detected was type 1, found in 65% of the chronic hepatitis patients
and in 88% of the hemodialysis patients. Subtype 1b was the most
prevalent and was detected in >40% of the chronic hepatitis
patients and in >70% of the dialysis patients. Other types
detected were 2a and 3, and in only two patients was type 4 found.
More than 50% of patients with type 1 (1a or 1b) among patients
with chronic hepatitis had received blood transfusion in the past,
but only 16.6% of patients bearing subtype 2a HCV had such a
history. Our preliminary evaluation revealed that patients bearing
subtype 1b seemed to have a better response to interferon
treatment, as compared with patients infected with subtypes 1a, 2a,
who displayed a low response rate.
Author: R TURKASPA, RABIN MED CTR, DEPT MED D, BELINSON
CAMPUS, IL-49100 PETAH TIQWA, ISRAEL
Source: ISRAEL JOURNAL OF MEDICAL SCIENCES 1997
JAN;33(1):18-22
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