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J Med Virol 2000 Feb;60(2):122-125
Changes in the epidemiology of hepatitis C infection in Germany:
Shift in the predominance of hepatitis C subtypes.
Ross RS, Viazov S, Renzing-Kohler K, Roggendorf M; Institute of
Virology, National Reference Centre for Hepatitis C, University of
Essen, Essen, Germany.
[Record supplied by publisher]
Hepatitis C virus (HCV) subtype distribution was studied in 395
chronically infected patients from Germany. HCV genotype 1 was most
frequent (80.5%). One hundred forty-three individuals (36.2%) were
infected with subtype 1a and 175 (44.3%) were suffering from
subtype 1b infection, respectively. HCV subtype 3a was found in 53
(13.42%) persons. Subtypes 2a, 2b, and 2c have been detected in 5
(1.27%), 10 (2.53%), and 4 (1.01%) individuals. Genotypes 4 and 5a
accounted for HCV infections in 4 (1.01%) and 1 (0.25%) subjects.
There was a notable variation in the distribution of the prevalent
subtypes 1a and 1b in different age groups. Subtype 1a was detected
in 53.3% and 68.0% of patients aged 1-10 and 11-20 years, whereas
subtype 1b in the same groups was present only in 33.3% and 28.0%
of patients, respectively. In contrast, in individuals older than
50 years subtype 1b was most frequent. Thus, subtype 1b has been
gradually substituted for subtype 1a during the last 20 years.
Logistic regression analysis with adjustment for sex and different
modes of HCV acquisition demonstrated that age of the infected
subjects was a direct explanatory variable for subtype 1a and 1b
distribution. Therefore, the observed shift in HCV subtype
prevalence could not be attributed to changes in the
epidemiological relevance of different known risk factors of HCV
transmission, as had been assumed in previous studies. The altered
subtype pattern reported here may have a profound influence on the
future epidemiology of HCV infection. Copyright 2000 Wiley-Liss,
Inc.
PMID: 10596009
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