Total Protein test Protein, total (TP), plasma or serum
Normal Range: 6-8 g/dL
SI Range: 60-80 g/L
Blood tube color: Marbled
Specfics of collection: Avoid prolonged venous stasis during
collection.
Physiologic Basis:
The plasma protein concentration is determined by the nutritional
state, hepatic function, renal function, and various disease states
and hydration. The plasma protein concentration determines
colloidal osmotic pressure.
Increased in: Polyclonal or monoclonal gammopathies, marked
dehydration. Drugs: anabolic steroids, androgens, corticosteroids,
epinephrine.
Decreased in: Protein-losing gastroenteropathies, acute burns,
nephrotic syndrome, severe dietary protein deficiency, chronic
liver disease, malabsorption syndrome, agammaglobulinemia.
Comments:
The serum total protein consists primarily of albumin and globulin.
Hypoproteinemia usually means hypoalbuminemia, since albumin is the
major serum protein. Globulin is calculated as total protein minus
albumin. Source: Nicoll D, S. J. McPhee, T. M. Chou, W. M.
Detmer. Pocket Guide to Diagnostic Tests. Appleton & Lange,
1996.
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