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Detection and Genotyping of HCV RNA in Tear Fluid
Tear fluid from 51 patients with chronic hepatitis C virus (HCV)
infection was analyzed for the presence of the hepatitis C RNA to
assess the potential role of this fluid in virus transmission. HCV
sequences were amplified from sera and tear fluids by nested
olymerase chain reaction using primers from the 5' non coding
region of the virus genome. Positive samples were genotyped by the
LiPA(TM) procedure. HCV RNA was detected in 76.5% (39/51) of the
sera and in 9.8% (5/51) of the tear fluid samples. The pres ence of
the RNA in the tear fluid was independent of the severity of the
hepatitis and of the viral load as measured by the branched DNA(TM)
assay. The genotypes of the tears and serum isolates were different
for two patients. For another patient, the HCV RNA was positive in
the tear sample but negative in the serum sample. These findings
suggest that tear fluid may transmit HCV but the source of HCV RNA
in this fluid needs to be better understood. (C) Wiley-Liss,
Inc.
Author: MENDEL I, CHU CHARLES NICOLLE, F-76031 ROUEN, FRANCE
Source: JOURNAL OF MEDICAL VIROLOGY 1997 MAR;51(3):231-233
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