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Lack of evidence for the heterosexual transmission of hepatitis
C
Gordon SC; Patel AH; Kulesza GW; Barnes RE; Silverman AL
Department of Internal Medicine, William Beaumont Hospital, Royal
Oak, Michigan
Am J Gastroenterol 87: 1849-51 (1992)
ABSTRACT:
To determine the potential for sexual transmission of the hepatitis
C virus (HCV), we specifically studied a cohort of 42 young adults
(median age, 39 yr) with chronic HCV infection and their stable
sexual partners. All HCV assays were supplemented with the
four-antigen recombinant immunoblot assay, and 39 of 42 partners
were tested for HCV RNA by the nested polymerase chain reaction.
Ninety percent of the partners reported frequent and unprotected
sexual intercourse with the index patients. Two of 42 partners
tested positive for the anti-HCV antibody and both were HCV RNA
positive; one had independent risk factors for viral hepatitis.
Therefore, one of 41 partners, (2.4%; 95% CI, 0.6-12.9%) without
independent risk factors for HCV was anti-HCV positive. This woman
was one of five partners (20%; 95% CI, 1-66%) who reported frequent
razor-sharing with the index patient. The partner frequently
sustained skin lacerations, with bleeding, secondary to this shared
razor blade. We conclude that heterosexual transmission of
hepatitis C is extremely uncommon, despite frequent and unprotected
sexual intercourse.
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