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TITLE: Sexual and non-sexual intrafamilial spread of
hepatitis C virus: Intrafamilial transmission of HCV
Abstract: The rate of intrafamilial transmission of the
hepatitis C virus (HCV) was investigated in 90 family members of 41
index patients with type C chronic liver disease. Antibody to HCV
(anti-HCV) was detected by the EIA method (Abbott-Axsym Sys) and
Hepatitis C virus RNA, by the polymerase chain reaction (Nested
PCR). We also investigated the presence of anti-HCV in 350 healthy
persons (control group). The subjects in the study included 38
spouses, 45 children and others (1 relative and 6 parents). Four
family members including 3/38 (7.8%) spouses and 1 sister were
found to be positive for anti HCV antibodies but none had HCV RNA.
Anti-HCV was not detected in the children of index patients. The
prevalence of anti-HCV in the families of index patients was
significantly higher than in the controls (4.3% versus 0.85%) (p =
0.0355). We concluded that the intrafamilial transmission of HCV is
possible but occurs at a low rate.
AUTHOR: Saltoglu N, Tasova Y, Burgut R, Dundar IH; SOURCE:
EUROPEAN JOURNAL OF EPIDEMIOLOGY 14: (3) 225-228 APR 1998
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